This guide-2013 is designed to facilitate the work [1] design of clinical studies carried out by researchers [2] assessment by members of the CIS and [3] of information to patients, guardian , elected representatives or guardians of fact to which are invited to participate in a clinical trial. Collects and sorts all the ethical and legal imperative scattered in different declarations, guidelines, international guidelines, Spanish legislation and good practice documents; proposes new ethical guidelines to keep in mind, they are not required but it would be desirable, and reflects and elaborates on some controversial aspects. nn
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